Non-structural protein 9 nsp9
UniProt ITasser SWISS Models alphafold D3Targets-2019-nCoVMay participate in viral replication by acting as a ssRNA-binding protein
Models/PDB
No model built for protein with good structural coverage represented in PDB
| Models/PDB | Model Chains_ID | Selected Templates | Model-Quality (MolProbity) | PDB Coverage | Model Coverage | Sequence Length | Oligomer States | Oligomer Interfaces | Model information |
|---|---|---|---|---|---|---|---|---|---|
| X-RAY_6W9Q | A,B | 6W9Q; Solved experimentally with good Coverage; | NA | 100% | 0.00% | 113 | Homo 2-mer |
NA |
NA |
Binding Site Predictions
The fpocket calculation in this table only for structure present in the Model/PDB table above.
| fpocket | pocket score | drug score | hydrophobicity score | polarity score |
|---|---|---|---|---|
| pocket0_nsp9 | 37.49 | 0.62 | 12.5 | 13 |
| pocket1_nsp9 | 37.49 | 0.62 | 12.5 | 13 |
| pocket2_nsp9 | 12.53 | 0.02 | 17.56 | 6 |
| pocket3_nsp9 | 12.16 | 0.01 | 17.56 | 6 |
| pocket4_nsp9 | 9.06 | 0.03 | 26.7 | 5 |
| pocket5_nsp9 | 9.06 | 0.03 | 26.7 | 7 |
| pocket6_nsp9 | 7.61 | 0.02 | 27.25 | 3 |
| pocket7_nsp9 | 6.53 | 0.02 | 17.71 | 4 |
UniProt Viewer
Predictions of Mutations
| pdb_id | mutations | deepddg | maestro | mCSM_ppi | mCSM_Stability | imutant | provean |
|---|---|---|---|---|---|---|---|
| 6w4b | K82A | -0.255 | -0.18 | -0.605 | 0.067 | Decrease | 0.895 |
| 6w4b | K82C | -0.462 | -0.026 | -0.019 | -0.264 | Increase | 0.308 |
| 6w4b | K82D | -0.089 | -0.381 | -0.208 | -0.112 | Increase | -0.044 |
| 6w4b | K82E | -0.4 | -0.502 | -0.239 | -0.115 | Increase | 0.081 |
| 6w4b | K82G | -0.342 | -0.269 | -0.59 | -0.097 | Decrease | 0.286 |
| 6w4b | K82I | -0.069 | 0.156 | -0.635 | 0.415 | Decrease | 2.008 |
| 6w4b | K82L | -0.191 | 0.173 | -0.635 | 0.415 | Increase | 1.234 |
| 6w4b | K82M | -0.25 | 0.118 | 0.462 | 0.027 | Increase | 1.084 |
| 6w4b | K82N | 0 | -0.207 | -0.73 | 0.167 | Decrease | 0.457 |
| 6w4b | K82P | -0.547 | -0.236 | -0.627 | 0.325 | Increase | -0.005 |
| 6w4b | K82Q | -0.165 | -0.32 | -0.549 | 0.018 | Increase | 0.158 |
| 6w4b | K82R | -0.265 | -0.502 | -0.602 | -0.039 | Decrease | 0.028 |
| 6w4b | K82S | -0.095 | -0.342 | -0.605 | -0.236 | Increase | 0.487 |
| 6w4b | K82T | -0.263 | -0.218 | -0.606 | -0.108 | Increase | 1.131 |
| 6w4b | K82V | -0.376 | -0.05 | -0.627 | 0.325 | Increase | 2.249 |
| 6w4b | K82Y | -0.607 | 0.185 | 0.044 | -0.02 | Increase | 0.56 |
| 6w4b | T20D | -0.642 | -0.078 | -0.218 | -0.279 | Decrease | 0.901 |
| 6w4b | T20E | -0.727 | 0.199 | -0.301 | -0.33 | Decrease | -0.134 |
| 6w4b | T20N | -1.064 | -0.02 | -0.543 | -0.436 | Increase | 0.242 |
| 6w4b | T20P | -1.755 | 0.142 | -0.117 | -0.451 | Decrease | 0.223 |
| 6w4b | T20Q | -1.9 | 0.116 | -0.442 | -0.717 | Decrease | -0.605 |
| 6w4b | T20S | -0.578 | 0.171 | -0.423 | -0.787 | Decrease | 0.037 |
| 6w4b | T63D | -0.256 | -0.485 | 0.086 | -0.002 | Decrease | -0.578 |
| 6w4b | T63E | -0.528 | -0.681 | 0.067 | -0.101 | Decrease | -0.613 |
| 6w4b | T63G | -0.761 | 0.041 | -0.038 | -0.303 | Decrease | -0.994 |
| 6w4b | T63H | -0.828 | 0.079 | 0.638 | -0.498 | Decrease | -0.264 |
| 6w4b | T63K | -0.403 | -0.24 | 0.275 | -0.264 | Decrease | 0.022 |
| 6w4b | T63M | -0.281 | -0.038 | 0.618 | -0.171 | Decrease | -0.695 |
| 6w4b | T63N | -0.093 | -0.211 | -0.156 | -0.056 | Decrease | 0.649 |
| 6w4b | T63Q | -0.37 | -0.629 | 0.008 | -0.285 | Decrease | -0.411 |
| 6w4b | T63R | -0.408 | -0.445 | 0.282 | -0.011 | Decrease | -0.708 |
| 6w4b | T63S | -0.45 | -0.142 | -0.139 | -0.223 | Decrease | 0.434 |
SAR CoV-2 & Human Proteins interaction
To download all protein-protein docking models please see the Help page
| PPI docking | CHARMM_ENERGY | pdb_human | human_genes |
|---|---|---|---|
| 4ndnE-nsp9.003.01.min | -12934.67 | 4ndn_E | MAT2B |
| 4ndnE-nsp9.003.21.min | -12874.1 | 4ndn_E | MAT2B |
| 4ndnE-nsp9.003.16.min | -12867.69 | 4ndn_E | MAT2B |
| 4ndnE-nsp9.003.12.min | -12827.64 | 4ndn_E | MAT2B |
| 5iybT-nsp9.003.14.min | -10173.19 | 5iyb_T | GTF2F2 |
| 5iybT-nsp9.001.07.min | -10053.5 | 5iyb_T | GTF2F2 |
| 5iybT-nsp9.001.17.min | -10051.85 | 5iyb_T | GTF2F2 |
| 5iybT-nsp9.003.09.min | -10027.15 | 5iyb_T | GTF2F2 |
Protein-Protein Interactions
We have mapped SARS CoV-2 human Protein-Protein Interactions from A SARS-CoV-2 protein interaction map reveals targets for drug repurposing human drug target interacted with SARS CoV-2 are highlighted in black arrow.
