Non-structural protein 8 nsp8
UniProt ITasser SWISS Models alphafold D3Targets-2019-nCoVForms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.
Models/PDB
No model built for protein with good structural coverage represented in PDB
Binding Site Predictions
The fpocket calculation in this table only for structure present in the Model/PDB table above.
| fpocket | pocket score | drug score | hydrophobicity score | polarity score |
|---|---|---|---|---|
| pocket0_nsp8 | 37.2 | 0.81 | 36.57 | 14 |
| pocket1_nsp8 | 27.54 | 0.04 | 3.46 | 16 |
| pocket2_nsp8 | 25.63 | 0.25 | 28.65 | 11 |
| pocket3_nsp8 | 20.1 | 0.16 | 22.53 | 11 |
| pocket4_nsp8 | 18.83 | 0.09 | 35.9 | 12 |
| pocket5_nsp8 | 16.4 | 0.06 | 5.2 | 10 |
| pocket6_nsp8 | 14.92 | 0.02 | 14.47 | 10 |
| pocket7_nsp8 | 14.26 | 0.03 | 11.83 | 7 |
| pocket8_nsp8 | 14.19 | 0.09 | 37.05 | 8 |
| pocket9_nsp8 | 12 | 0.11 | 47.67 | 9 |
| pocket10_nsp8 | 11.94 | 0.19 | 49 | 6 |
| pocket11_nsp8 | 11.01 | 0.07 | 38.79 | 10 |
| pocket12_nsp8 | 10.81 | 0.02 | 16.77 | 9 |
| pocket13_nsp8 | 10.81 | 0.03 | 27.43 | 8 |
| pocket14_nsp8 | 10.71 | 0.02 | 9.4 | 6 |
| pocket15_nsp8 | 10.44 | 0.01 | 17.13 | 7 |
| pocket16_nsp8 | 10.17 | 0.04 | 35.6 | 6 |
| pocket0_nsp8 | 31.53 | 0.04 | -1 | 11 |
| pocket1_nsp8 | 29.69 | 0.05 | 20.92 | 5 |
| pocket2_nsp8 | 29.66 | 0.02 | 14.91 | 8 |
UniProt Viewer
Other PDB Hits
| ID | Method | Resolution Å | Chains | Links |
|---|---|---|---|---|
| 7cxm | CRYO_EM | 2.9 | B, D; |
PDBe
RCSB PDB |
| 7cxn | CRYO_EM | 3.84 | B, D; |
PDBe
RCSB PDB |
| 7ctt | CRYO_EM | 3.2 | A, B, D, C, Q, T; |
PDBe
RCSB PDB |
| 7jlt | X-RAY | 2.7 | A, B, C, D |
PDBe
RCSB PDB |
| 6xip | X-RAY | 1.5 | B,D |
PDBe
RCSB PDB |
| 6m5i | X-RAY | 2.5 | B |
PDBe
RCSB PDB |
| 6wtc | X-RAY | 1.85 | B |
PDBe
RCSB PDB |
| 6wqd | X-RAY | 1.95 | A |
PDBe
RCSB PDB |
| 6yhu | X-RAY | 2 | A,B,C,D |
PDBe
RCSB PDB |
| 6wiq | X-RAY | 2.85 | A,B |
PDBe
RCSB PDB |
| 6yyt | CRYO_EM | 2.9 | A,B,C,D,P,Q,T,U |
PDBe
RCSB PDB |
| 6m71 | CRYO_EM | 2.9 | A,C,D,B |
PDBe
RCSB PDB |
| 7bv1 | CRYO_EM | 2.8 | A,B,C,D |
PDBe
RCSB PDB |
| 7bzf | CRYO_EM | 3.26 | A,B,C,D,F,G |
PDBe
RCSB PDB |
| 6wkq | X-RAY | 1.9 | A,B |
PDBe
RCSB PDB |
| 6xez | CRYO_EM | 3.5 | A,B,C,D,E,F |
PDBe
RCSB PDB |
| 7bv2 | X-RAY | 2.5 | B |
PDBe
RCSB PDB |
| 7btf | CRYO_EM | 2.95 | B |
PDBe
RCSB PDB |
| 7aap | CRYO_EM | 2.6 | A, B, C; |
PDBe
RCSB PDB |
SAR CoV-2 & Human Proteins interaction
To download all protein-protein docking models please see the Help page
| PPI docking | CHARMM_ENERGY | pdb_human | human_genes |
|---|---|---|---|
| 2nn6C-nsp8.003.00.min | -13554.62 | 2nn6_C | EXOSC2 |
| 2nn6C-nsp8.002.15.min | -13470.72 | 2nn6_C | EXOSC2 |
| 2nn6C-nsp8.002.21.min | -13469.76 | 2nn6_C | EXOSC2 |
| 2nn6C-nsp8.003.02.min | -13437.16 | 2nn6_C | EXOSC2 |
| 2nn6G-nsp8.000.12.min | -12020.3 | 2nn6_G | EXOSC2 |
| 2nn6G-nsp8.000.07.min | -11980.85 | 2nn6_G | EXOSC2 |
| 2nn6G-nsp8.001.17.min | -11980.85 | 2nn6_G | EXOSC2 |
| 2nn6G-nsp8.002.16.min | -11980.85 | 2nn6_G | EXOSC2 |
| 4zdlA-nsp8.003.07.min | -19563.81 | 4zdl_A | SEPSECS |
| 4zdlA-nsp8.003.13.min | -19430.16 | 4zdl_A | SEPSECS |
| 4zdlA-nsp8.001.27.min | -19428.24 | 4zdl_A | SEPSECS |
| 4zdlA-nsp8.003.02.min | -19419.08 | 4zdl_A | SEPSECS |
| 2nn6D-nsp8.002.08.min | -11400.63 | 2nn6_D | EXOSC2 |
| 2nn6D-nsp8.000.26.min | -11394.22 | 2nn6_D | EXOSC2 |
| 2nn6D-nsp8.001.18.min | -11384.87 | 2nn6_D | EXOSC2 |
| 2nn6D-nsp8.001.02.min | -11370.71 | 2nn6_D | EXOSC2 |
| 2nn6H-nsp8.001.13.min | -12168.87 | 2nn6_H | EXOSC2 |
| 2nn6H-nsp8.000.01.min | -12067.41 | 2nn6_H | EXOSC2 |
| 2nn6H-nsp8.001.01.min | -12067.41 | 2nn6_H | EXOSC2 |
| 2nn6H-nsp8.001.25.min | -12038.8 | 2nn6_H | EXOSC2 |
Protein-Protein Interactions
We have mapped SARS CoV-2 human Protein-Protein Interactions from A SARS-CoV-2 protein interaction map reveals targets for drug repurposing human drug target interacted with SARS CoV-2 are highlighted in black arrow.
