Non-structural protein 7 nsp7
UniProt ITasser SWISS Models alphafold D3Targets-2019-nCoVForms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.
Models/PDB
No model built for protein with good structural coverage represented in PDB
Binding Site Predictions
The fpocket calculation in this table only for structure present in the Model/PDB table above.
| fpocket | pocket score | drug score | hydrophobicity score | polarity score |
|---|---|---|---|---|
| pocket0_nsp7 | 31.53 | 0.04 | -1 | 11 |
| pocket1_nsp7 | 29.69 | 0.05 | 20.92 | 5 |
| pocket2_nsp7 | 29.66 | 0.02 | 14.91 | 8 |
UniProt Viewer
Other PDB Hits
| ID | Method | Resolution Å | Chains | Links |
|---|---|---|---|---|
| 7cxm | CRYO_EM | 2.9 | C |
PDBe
RCSB PDB |
| 7cxn | CRYO_EM | 3.84 | C |
PDBe
RCSB PDB |
| 6wkq | X-RAY | 1.9 | A,B |
PDBe
RCSB PDB |
| 6yhu | X-RAY | 2 | A,B,C,D |
PDBe
RCSB PDB |
| 6wiq | X-RAY | 2.85 | A,B |
PDBe
RCSB PDB |
| 6m71 | CRYO_EM | 2.9 | A,C,D,B |
PDBe
RCSB PDB |
| 7bv1 | CRYO_EM | 2.8 | A,B,C,D |
PDBe
RCSB PDB |
| 7bzf | CRYO_EM | 3.26 | A,B,C,D,F,G |
PDBe
RCSB PDB |
| 7bv2 | X-RAY | 2.5 | C |
PDBe
RCSB PDB |
| 6xez | CRYO_EM | 3.5 | A,B,C,D,E,F |
PDBe
RCSB PDB |
| 7btf | CRYO_EM | 2.95 | C |
PDBe
RCSB PDB |
| 6wqd | X-RAY | 1.95 | A |
PDBe
RCSB PDB |
| 6wtc | X-RAY | 1.85 | A |
PDBe
RCSB PDB |
| 6yyt | CRYO_EM | 1.85 | C |
PDBe
RCSB PDB |
| 6m5i | X-RAY | 2.5 | A |
PDBe
RCSB PDB |
| 6xip | X-RAY | 1.5 | A,C |
PDBe
RCSB PDB |
| 7jlt | X-RAY | 2.7 | A, B, C, D |
PDBe
RCSB PDB |
| 7ctt | CRYO_EM | 3.2 | A, B, D, C, Q, T; |
PDBe
RCSB PDB |
| 7aap | CRYO_EM | 2.6 | A, B, C; |
PDBe
RCSB PDB |
SAR CoV-2 & Human Proteins interaction
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Protein-Protein Interactions
We have mapped SARS CoV-2 human Protein-Protein Interactions from A SARS-CoV-2 protein interaction map reveals targets for drug repurposing human drug target interacted with SARS CoV-2 are highlighted in black arrow.
