Non-structural protein 6 nsp6
UniProt ITasser SWISS Models alphafold D3Targets-2019-nCoVPlays a role in the initial induction of autophagosomes from host reticulum endoplasmic. Later, limits the expansion of these phagosomes that are no longer able to deliver viral components to lysosomes
Models/PDB
No model built for protein with good structural coverage represented in PDB
| Models/PDB | Model Chains_ID | Selected Templates | Model-Quality (MolProbity) | PDB Coverage | Model Coverage | Sequence Length | Oligomer States | Oligomer Interfaces | Model information |
|---|---|---|---|---|---|---|---|---|---|
| nsp6 | A | AlphaFold Prediction; | 0.85 | 0.00% | 100.00% | 290 | monomer |
NA |
nsp6 |
Binding Site Predictions
The fpocket calculation in this table only for structure present in the Model/PDB table above.
| fpocket | pocket score | drug score | hydrophobicity score | polarity score |
|---|---|---|---|---|
| pocket0_nsp6 | 38.78 | 0.87 | 41.47 | 10 |
| pocket1_nsp6 | 30.02 | 0.3 | 31.17 | 11 |
| pocket2_nsp6 | 24.86 | 0.84 | 52.8 | 5 |
| pocket0_nsp6 | 20.05 | 0.07 | 19.5 | 7 |
UniProt Viewer
SAR CoV-2 & Human Proteins interaction
To download all protein-protein docking models please see the Help page
| PPI docking | CHARMM_ENERGY | pdb_human | human_genes |
|---|---|---|---|
| 5hk1A-nsp6.003.28.min | -13899.02 | 5hk1_A | SIGMAR1 |
| 5hk1A-nsp6.003.04.min | -13885.01 | 5hk1_A | SIGMAR1 |
| 5hk1A-nsp6.003.07.min | -13865.33 | 5hk1_A | SIGMAR1 |
| 5hk1A-nsp6.003.01.min | -13855.26 | 5hk1_A | SIGMAR1 |
Protein-Protein Interactions
We have mapped SARS CoV-2 human Protein-Protein Interactions from A SARS-CoV-2 protein interaction map reveals targets for drug repurposing human drug target interacted with SARS CoV-2 are highlighted in black arrow.
