SARS-CoV-2 3D

Non-structural protein 2 nsp2

UniProt ITasser SWISS Models alphafold D3Targets-2019-nCoV

May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses

Models/PDB

No model built for protein with good structural coverage represented in PDB

Models/PDB	Model Chains_ID	Selected Templates	Model-Quality (MolProbity)	PDB Coverage	Model Coverage	Sequence Length	Oligomer States	Oligomer Interfaces	Model information
nsp2 Download Pdb file	A	5F22_B; 3LD1_A; 5Y81_H; 1R7G_A; 1G03_A;	2.31	0.00%	100.00%	638	monomer	NA Download interfaces pdf	nsp2 Download model information txt

Models/PDB

Model Chains_ID

Selected Templates

Model-Quality (MolProbity)

PDB Coverage

Model Coverage

Sequence Length

Oligomer States

Oligomer Interfaces

Model information

nsp2

Download Pdb file

5F22_B; 3LD1_A; 5Y81_H; 1R7G_A; 1G03_A;

2.31

0.00%

100.00%

638

monomer

Download interfaces pdf

nsp2

Download model information txt

Binding Site Predictions

The fpocket calculation in this table only for structure present in the Model/PDB table above.

fpocket	pocket score	drug score	hydrophobicity score	polarity score
pocket0_nsp2	32.63	0.72	25.89	17
pocket1_nsp2	32.2	0.1	26.76	18
pocket2_nsp2	29.99	0.09	27.33	16
pocket3_nsp2	21.88	0.15	19.71	10
pocket4_nsp2	17.27	0.01	-14.5	12
pocket5_nsp2	16.08	0.14	30	9
pocket6_nsp2	15.88	0.04	26.09	10
pocket7_nsp2	14.93	0.04	26.26	13
pocket8_nsp2	12.6	0.04	35.71	7

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SAR CoV-2 & Human Proteins interaction

To download all protein-protein docking models please see the Help page

PPI docking	CHARMM_ENERGY	pdb_human	human_genes
3qe2A-nsp2.003.06.min Download Pdb file	-38509.16	3qe2_A	POR
3qe2A-nsp2.003.20.min Download Pdb file	-38474.05	3qe2_A	POR
3qe2A-nsp2.002.24.min Download Pdb file	-38473.15	3qe2_A	POR
3qe2A-nsp2.001.18.min Download Pdb file	-38456.57	3qe2_A	POR

Protein-Protein Interactions

We have mapped SARS CoV-2 human Protein-Protein Interactions from A SARS-CoV-2 protein interaction map reveals targets for drug repurposing human drug target interacted with SARS CoV-2 are highlighted in black arrow.