SARS-CoV-2 3D

Non-structural protein 10 nsp10

UniProt ITasser SWISS Models alphafold D3Targets-2019-nCoV

Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities. Therefore plays an essential role in viral mRNAs cap methylation

Models/PDB

No model built for protein with good structural coverage represented in PDB

Models/PDB	Model Chains_ID	Selected Templates	Model-Quality (MolProbity)	PDB Coverage	Model Coverage	Sequence Length	Oligomer States	Oligomer Interfaces	Model information
nsp10 Download Pdb file	A	6ZCT; 5C8T;	3.16	81.29%	94%	139	Hetero 2-mer	nsp10 Download interfaces pdf	nsp10 Download model information txt

Models/PDB

Model Chains_ID

Selected Templates

Model-Quality (MolProbity)

PDB Coverage

Model Coverage

Sequence Length

Oligomer States

Oligomer Interfaces

Model information

nsp10

Download Pdb file

6ZCT; 5C8T;

3.16

81.29%

94%

139

Hetero 2-mer

nsp10

Download interfaces pdf

nsp10

Download model information txt

Binding Site Predictions

The fpocket calculation in this table only for structure present in the Model/PDB table above.

fpocket	pocket score	drug score	hydrophobicity score	polarity score
pocket0_nsp10	37.72	0.37	35.89	11
pocket1_nsp10	25.25	0.77	51.29	3
pocket2_nsp10	14.88	0.01	11	4
pocket22_nsp10	5.7463	0.0157	19.7333	10
pocket3_nsp10	18.3922	0.0891	13.7778	11
pocket17_nsp10	8.1419	0.0135	10.6923	6
pocket8_nsp10	10.8626	0.019	18.5455	7
pocket29_nsp10	0.4594	0.023	34.5	5
pocket11_nsp10	9.2691	0.0214	12.8182	7
pocket5_nsp10	15.4398	0.653	48.5556	9
pocket30_nsp10	-0.4836	0.0968	55.0909	3
pocket24_nsp10	5.0091	0.1936	60.8182	5
pocket23_nsp10	5.5603	0.0074	3.1667	8
pocket2_nsp10	21.8839	0.2341	40.44	11
pocket16_nsp10	8.2235	0.0233	31.6923	5
pocket9_nsp10	9.938	0.0241	23.2667	7
pocket28_nsp10	2.4249	0.0265	37.6	4
pocket10_nsp10	9.3637	0.0107	8.8333	5
pocket4_nsp10	16.5917	0.1107	32.2941	10
pocket25_nsp10	3.5906	0.0053	-8.25	5
pocket18_nsp10	8.0101	0.1901	41.2308	6
pocket1_nsp10	27.6447	0.0771	19.4375	19
pocket15_nsp10	8.2262	0.0127	19.4545	7
pocket20_nsp10	7.4516	0.0118	21.2308	6
pocket26_nsp10	3.4862	0.0495	36.625	4
pocket13_nsp10	8.9172	0.0163	22.6154	8
pocket7_nsp10	11.5009	0.1179	32.5714	7
pocket19_nsp10	7.5235	0.0069	-0.8333	8
pocket0_nsp10	41.144	0.6056	18.5938	17
pocket14_nsp10	8.2722	0.009	2.1111	5
pocket21_nsp10	5.7501	0.0176	28.8	6
pocket27_nsp10	2.4657	0.0095	18.3636	5
pocket12_nsp10	9.079	0.0276	21.4545	6
pocket6_nsp10	13.7729	0.0773	13.6667	7

UniProt Viewer

Other PDB Hits

ID	Method	Resolution Å	Chains	Links
6wq3	X-RAY	2.1	B	PDBe RCSB PDB
6w75	X-RAY	1.95	B	PDBe RCSB PDB
6yz1	X-RAY	2.4	A,B	PDBe RCSB PDB
6w4h	X-RAY	1.8	A,B	PDBe RCSB PDB
6w61	X-RAY	2	A,B	PDBe RCSB PDB
7c2i	X-RAY	2.5	A,B	PDBe RCSB PDB
6ZCT	X-RAY	2.55	A	PDBe RCSB PDB
6wks	CRYO_EM	1.8	AAA,BBB	PDBe RCSB PDB
6wjt	X-RAY	2	B	PDBe RCSB PDB
6wrz	X-RAY	2.25	B	PDBe RCSB PDB
6wvn	X-RAY	2	B	PDBe RCSB PDB
7c2j	X-RAY	2.8	B	PDBe RCSB PDB
7bq7	X-RAY	2.37	B	PDBe RCSB PDB
6xkm	X-RAY	2.25	B	PDBe RCSB PDB
7jpe	X-RAY	2.18	A, B	PDBe RCSB PDB
7jib	X-RAY	2.65	A, B	PDBe RCSB PDB
7jhe	X-RAY	2.25	A, B	PDBe RCSB PDB
7jz0	X-RAY	2.15	A, C, A, C, B, D, E, F;	PDBe RCSB PDB
7jyy	X-RAY	2.05	A, C, A, C, B, D, E, F;	PDBe RCSB PDB
6zpe	X-RAY	1.58	A;	PDBe RCSB PDB

Protein-Protein Interactions

We have mapped SARS CoV-2 human Protein-Protein Interactions from A SARS-CoV-2 protein interaction map reveals targets for drug repurposing human drug target interacted with SARS CoV-2 are highlighted in black arrow.