ORF9c
UniProt ITasser SWISS Models alphafold D3Targets-2019-nCoVMay play a role in host-virus interaction.
Models/PDB
No model built for protein with good structural coverage represented in PDB
UniProt Viewer
Predictions of Mutations
| pdb_id | mutations | deepddg | maestro | mCSM_ppi | mCSM_Stability | imutant | provean |
|---|---|---|---|---|---|---|---|
| orf9c | L71R | -0.392 | -1.637672 | -0.1 | 0.027 | Decrease | 0 |
| orf9c | C14R | -0.347 | -1.594779 | -0.775 | 0.273 | Decrease | -12 |
| orf9c | M1Q | -0.311 | -1.553298 | -0.035 | 0.425 | Decrease | -5 |
| orf9c | M1E | -0.387 | -1.552442 | 0.373 | 0.181 | Decrease | -7 |
| orf9c | T19R | -0.385 | -1.540735 | 0.247 | -0.052 | Increase | -6 |
| orf9c | M1D | -0.468 | -1.526006 | 0.341 | 0.233 | Decrease | -8 |
| orf9c | M1K | -0.426 | -1.490648 | -0.043 | 0.405 | Decrease | -6 |
| orf9c | V62R | -0.811 | -1.472967 | -1.673 | -0.345 | Decrease | -7 |
| orf9c | M1R | -0.443 | -1.448868 | -0.384 | 0.754 | Decrease | -6 |
| orf9c | L71D | -0.441 | -1.429017 | 0.802 | -0.293 | Decrease | 0 |
| orf9c | Q3W | 0.087 | -1.423048 | -1.814 | -0.284 | Decrease | -2.375 |
| orf9c | V37R | -0.957 | -1.418256 | -1.054 | -0.142 | Decrease | -7 |
| orf9c | I43R | -0.898 | -1.397118 | -1.011 | -0.055 | Decrease | -6.625 |
| orf9c | V40R | -0.944 | -1.389811 | -1.706 | -0.149 | Decrease | -6 |
| orf9c | M1N | -0.42 | -1.374978 | -0.305 | 0.56 | Decrease | -7 |
| orf9c | L71E | -0.428 | -1.351654 | 0.821 | -0.391 | Decrease | 0 |
| orf9c | L71Q | -0.281 | -1.342132 | 0.442 | -0.371 | Decrease | 0 |
| orf9c | T72R | -0.589 | -1.313319 | -0.317 | -0.108 | Increase | 0 |
| orf9c | C68R | -0.219 | -1.295862 | -0.811 | 0.307 | Decrease | 0 |
| orf9c | S4I | -0.156 | -1.29556 | -0.577 | -0.191 | Increase | -2.75 |
| orf9c | Q3Y | -0.74 | -1.291428 | -1.497 | -0.102 | Increase | -1.375 |
| orf9c | L71N | -0.412 | -1.281544 | 0.167 | -0.203 | Decrease | 0 |
| orf9c | C69R | -0.465 | -1.265457 | -0.562 | 0.332 | Increase | -12 |
| orf9c | G50E | -1.264 | -1.256007 | -0.478 | -0.358 | Increase | -8 |
| orf9c | L71K | -0.363 | -1.238588 | 0.35 | -0.368 | Decrease | 0 |
| orf9c | M1P | -0.709 | -1.230777 | -0.328 | 0.005 | Decrease | -7 |
| orf9c | T19Q | -0.304 | -1.227925 | 0.007 | -0.264 | Decrease | -6 |
| orf9c | G50D | -0.927 | -1.224635 | -0.381 | -0.237 | Decrease | -7 |
| orf9c | T19E | -0.467 | -1.200878 | 0.096 | -0.161 | Decrease | -6 |
| orf9c | C14K | -0.394 | -1.195572 | -0.855 | 0.003 | Decrease | -12 |
| orf9c | V49R | -0.578 | -1.18661 | -0.402 | -0.077 | Decrease | -7 |
| orf9c | A48R | -0.551 | -1.183583 | -0.737 | -0.243 | Decrease | -5 |
| orf9c | P29E | -0.857 | -1.174364 | -0.239 | -0.699 | Decrease | -8 |
| orf9c | L71S | -0.585 | -1.145979 | 0.184 | -0.56 | Decrease | 0 |
| orf9c | M1S | -0.748 | -1.139563 | -0.302 | 0.221 | Decrease | -6 |
| orf9c | H13R | -0.315 | -1.13888 | -1.416 | -0.589 | Decrease | -8 |
| orf9c | S4L | 0.228 | -1.136605 | -0.577 | -0.191 | Increase | -2.5 |
| orf9c | Q3I | -0.287 | -1.123503 | -0.861 | 0.105 | Increase | -0.75 |
| orf9c | S4M | -0.296 | -1.11984 | 0.153 | 0.133 | Increase | -1.875 |
| orf9c | S4Y | -0.446 | -1.107074 | -0.328 | -0.648 | Increase | -3.125 |
| orf9c | A47R | -0.563 | -1.099443 | -0.809 | -0.279 | Decrease | -5 |
| orf9c | Q3F | -0.103 | -1.095239 | -1.535 | -0.442 | Increase | -1.875 |
| orf9c | H34W | -0.372 | -1.08197 | -0.217 | 0.919 | Increase | -10 |
| orf9c | S4W | 0.287 | -1.07629 | -0.451 | -0.887 | Increase | -4.125 |
| orf9c | P33D | -1.524 | -1.065753 | -1.022 | -1.676 | Decrease | -5.375 |
| orf9c | G50Q | -0.756 | -1.061388 | -0.542 | -0.672 | Increase | -8 |
| orf9c | Q3L | 0.018 | -1.048814 | -0.861 | 0.105 | Increase | -0.125 |
| orf9c | T19K | -0.365 | -1.034225 | 0.255 | -0.262 | Decrease | -6 |
| orf9c | V37K | -1.032 | -1.032003 | -0.796 | -0.728 | Decrease | -6 |
| orf9c | L71P | -0.741 | -1.024215 | -0.067 | -0.438 | Decrease | 0 |
SAR CoV-2 & Human Proteins interaction
To download all protein-protein docking models please see the Help page
| PPI docking | CHARMM_ENERGY | pdb_human | human_genes |
|---|---|---|---|
| 3un9A-ORF9c1 | -1423.7 | 3un9_A | NLRX1 |
| 3un9A-ORF9c2 | -1351.7 | 3un9_A | NLRX1 |
| 3un9A-ORF9c3 | -1417.8 | 3un9_A | NLRX1 |
| 3un9A-ORF9c4 | -1407.8 | 3un9_A | NLRX1 |
| 5ndzA-ORF9c1 | -1306.7 | 5ndz_A | F2RL1 |
| 5ndzA-ORF9c2 | -1337.9 | 5ndz_A | F2RL1 |
| 5ndzA-ORF9c3 | -1279.7 | 5ndz_A | F2RL1 |
| 5ndzA-ORF9c4 | -1328.8 | 5ndz_A | F2RL1 |
Protein-Protein Interactions
We have mapped SARS CoV-2 human Protein-Protein Interactions from A SARS-CoV-2 protein interaction map reveals targets for drug repurposing human drug target interacted with SARS CoV-2 are highlighted in black arrow.
