Plays a role in the inhibition of host innate immune response by targeting the mitochondrial-associated adapter MAVS. Mechanistically, usurps the E3 ligase ITCH to trigger the degradation of MAVS, TRAF3, and TRAF6. In addition, causes mitochondrial elongation by triggering ubiquitination and proteasomal degradation of dynamin-like protein 1/DNM1L
No model built for protein with good structural coverage represented in PDB
|Models/PDB||Model Chains_ID||Selected Templates||Model-Quality (MolProbity)||PDB Coverage||Model Coverage||Sequence Length||Oligomer States||Oligomer Interfaces||Model information|
The fpocket calculation in this table only for structure present in the Model/PDB table above.
|fpocket||pocket score||drug score||hydrophobicity score||polarity score|
We have mapped SARS CoV-2 human Protein-Protein Interactions from A SARS-CoV-2 protein interaction map reveals targets for drug repurposing human drug target interacted with SARS CoV-2 are highlighted in black arrow.