SARS-CoV-2 3D

ORF9b

UniProt ITasser SWISS Models alphafold D3Targets-2019-nCoV

Plays a role in the inhibition of host innate immune response by targeting the mitochondrial-associated adapter MAVS. Mechanistically, usurps the E3 ligase ITCH to trigger the degradation of MAVS, TRAF3, and TRAF6. In addition, causes mitochondrial elongation by triggering ubiquitination and proteasomal degradation of dynamin-like protein 1/DNM1L

Models/PDB

No model built for protein with good structural coverage represented in PDB

Models/PDB	Model Chains_ID	Selected Templates	Model-Quality (MolProbity)	PDB Coverage	Model Coverage	Sequence Length	Oligomer States	Oligomer Interfaces	Model information
ORF9b Download Pdb file	A,B	6Z4U;	2.3	87.63%	100.00%	97	Homo 2-mer	ORF9b Download interfaces pdf	ORF9b Download model information txt

Models/PDB

Model Chains_ID

Selected Templates

Model-Quality (MolProbity)

PDB Coverage

Model Coverage

Sequence Length

Oligomer States

Oligomer Interfaces

Model information

ORF9b

Download Pdb file

A,B

6Z4U;

2.3

87.63%

100.00%

Homo 2-mer

ORF9b

Download interfaces pdf

ORF9b

Download model information txt

Binding Site Predictions

The fpocket calculation in this table only for structure present in the Model/PDB table above.

fpocket	pocket score	drug score	hydrophobicity score	polarity score
pocket1_ORF9b	23.7348	0.104	32.4	8
pocket0_ORF9b	31.1101	0.963	70.8182	5
pocket3_ORF9b	10.2711	0.1067	44.1538	3
pocket2_ORF9b	20.8889	0.2427	40.2778	6

UniProt Viewer

Other PDB Hits

ID	Method	Resolution Å	Chains	Links
6z4u	X-RAY	1.95	A,B	PDBe RCSB PDB
7kdt	CRYO_EM	3.05	A, B;	PDBe RCSB PDB

Protein-Protein Interactions

We have mapped SARS CoV-2 human Protein-Protein Interactions from A SARS-CoV-2 protein interaction map reveals targets for drug repurposing human drug target interacted with SARS CoV-2 are highlighted in black arrow.