UniProt ITasser SWISS Models alphafold D3Targets-2019-nCoV

Plays a role in the inhibition of host innate immune response by targeting the mitochondrial-associated adapter MAVS. Mechanistically, usurps the E3 ligase ITCH to trigger the degradation of MAVS, TRAF3, and TRAF6. In addition, causes mitochondrial elongation by triggering ubiquitination and proteasomal degradation of dynamin-like protein 1/DNM1L


No model built for protein with good structural coverage represented in PDB

Models/PDB Model Chains_ID Selected Templates Model-Quality (MolProbity) PDB Coverage Model Coverage Sequence Length Oligomer States Oligomer Interfaces Model information
ORF9b A,B 6Z4U 2.3 87.63% 100.00% 97 Homo 2-mer



Binding Site Predictions

The fpocket calculation in this table only for structure present in the Model/PDB table above.

fpocket pocket score drug score hydrophobicity score polarity score
pocket1_ORF9b 23.7348 0.104 32.4 8
pocket0_ORF9b 31.1101 0.963 70.8182 5
pocket3_ORF9b 10.2711 0.1067 44.1538 3
pocket2_ORF9b 20.8889 0.2427 40.2778 6

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Other PDB Hits

ID Method Resolution Å Chains Links
6z4u X-RAY 1.95 A,B PDBe
7kdt CRYO_EM 3.05 A, B; PDBe

Protein-Protein Interactions

We have mapped SARS CoV-2 human Protein-Protein Interactions from A SARS-CoV-2 protein interaction map reveals targets for drug repurposing human drug target interacted with SARS CoV-2 are highlighted in black arrow.

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