SARS-CoV-2 3D

ORF6

UniProt ITasser SWISS Models alphafold D3Targets-2019-nCoV

Could be a determinant of virus virulence, since, when expressed in an otherwise attenuated JHM strain of murine coronavirus, it can dramatically increase the lethality of the latter. Seems to stimulate cellular DNA synthesis in vitro

Models/PDB

No model built for protein with good structural coverage represented in PDB

Models/PDB	Model Chains_ID	Selected Templates	Model-Quality (MolProbity)	PDB Coverage	Model Coverage	Sequence Length	Oligomer States	Oligomer Interfaces	Model information
ORF6 Download Pdb file	A	4GQT_A;	2.37	0.00%	100.00%	61	monomer	NA Download interfaces pdf	NA Download model information txt

Models/PDB

Model Chains_ID

Selected Templates

Model-Quality (MolProbity)

PDB Coverage

Model Coverage

Sequence Length

Oligomer States

Oligomer Interfaces

Model information

ORF6

Download Pdb file

4GQT_A;

2.37

0.00%

100.00%

monomer

Download interfaces pdf

Download model information txt

Binding Site Predictions

The fpocket calculation in this table only for structure present in the Model/PDB table above.

fpocket	pocket score	drug score	hydrophobicity score	polarity score
pocket0_ORF6	30.74	0.44	44.43	2

UniProt Viewer

SAR CoV-2 & Human Proteins interaction

To download all protein-protein docking models please see the Help page

PPI docking	CHARMM_ENERGY	pdb_human	human_genes
3mmyA-ORF6.001.25.min Download Pdb file	-12873.67	3mmy_A	RAE1
3mmyA-ORF6.003.08.min Download Pdb file	-12843.82	3mmy_A	RAE1
3mmyA-ORF6.003.00.min Download Pdb file	-12697.66	3mmy_A	RAE1
3mmyA-ORF6.003.06.min Download Pdb file	-12689.74	3mmy_A	RAE1

Protein-Protein Interactions

We have mapped SARS CoV-2 human Protein-Protein Interactions from A SARS-CoV-2 protein interaction map reveals targets for drug repurposing human drug target interacted with SARS CoV-2 are highlighted in black arrow.