ORF3d
UniProt ITasser SWISS Models alphafold D3Targets-2019-nCoVMay play a role in host modulation.
Models/PDB
No model built for protein with good structural coverage represented in PDB
UniProt Viewer
Predictions of Mutations
| pdb_id | mutations | deepddg | maestro | mCSM_ppi | mCSM_Stability | imutant | provean |
|---|---|---|---|---|---|---|---|
| orf3d | M1E | -0.721 | -1.445519 | -0.26 | 0.209 | Decrease | -7 |
| orf3d | C54Y | -0.774 | -1.419736 | -0.829 | -1.502 | Decrease | -11 |
| orf3d | N45W | -0.572 | -1.414201 | -0.629 | -0.446 | Decrease | -10 |
| orf3d | M1R | -0.704 | -1.404896 | -0.539 | 0.72 | Decrease | -6 |
| orf3d | T27R | -0.436 | -1.390836 | 0.15 | 0.023 | Decrease | -6 |
| orf3d | N45Y | -1.167 | -1.383367 | -0.278 | -0.162 | Decrease | -8 |
| orf3d | M1K | -0.738 | -1.378702 | -0.455 | 0.34 | Decrease | -6 |
| orf3d | L30N | -0.164 | -1.354116 | 0.045 | 0.218 | Decrease | -7 |
| orf3d | M1D | -0.911 | -1.338772 | -0.274 | 0.252 | Decrease | -8 |
| orf3d | L30Q | -0.353 | -1.338471 | 0.255 | 0.033 | Decrease | -6 |
| orf3d | L30D | -0.252 | -1.316677 | 0.669 | 0.212 | Decrease | -8 |
| orf3d | C54W | -0.797 | -1.313663 | -0.896 | -1.463 | Decrease | -11 |
| orf3d | M1Q | -0.548 | -1.272478 | -0.594 | 0.275 | Decrease | -5 |
| orf3d | H19Q | -0.284 | -1.254543 | -0.671 | 0.603 | Decrease | -8 |
| orf3d | H19R | -0.397 | -1.24118 | -1.304 | 0.23 | Decrease | -8 |
| orf3d | N45F | -0.553 | -1.241036 | -0.502 | -0.618 | Decrease | -9 |
| orf3d | S46Y | -1.082 | -1.24022 | -0.244 | -0.628 | Decrease | -6 |
| orf3d | H19E | -0.484 | -1.234355 | -0.788 | -0.146 | Increase | -8 |
| orf3d | L30E | -0.292 | -1.229615 | 0.662 | 0.108 | Increase | -7 |
| orf3d | F51E | -0.284 | -1.226399 | -0.699 | 0.628 | Decrease | -9 |
| orf3d | H19N | -0.376 | -1.225965 | -0.734 | 0.598 | Decrease | -7 |
| orf3d | S46W | -0.065 | -1.217383 | -0.585 | -0.886 | Decrease | -7 |
| orf3d | L30S | -0.736 | -1.195443 | 0.111 | -0.191 | Decrease | -6 |
| orf3d | C36R | -0.8 | -1.195246 | -1.448 | -0.056 | Decrease | -12 |
| orf3d | S46F | -0.177 | -1.186382 | -0.425 | -0.924 | Decrease | -6 |
| orf3d | T27K | -0.39 | -1.185158 | 0.215 | -0.147 | Decrease | -6 |
| orf3d | S46M | -0.149 | -1.139248 | -0.137 | 0.135 | Decrease | -5 |
| orf3d | S46L | -0.017 | -1.135689 | -0.333 | -0.195 | Decrease | -6 |
| orf3d | G32Q | -0.198 | -1.13534 | -0.284 | -0.623 | Decrease | -8 |
| orf3d | P21D | -0.873 | -1.130375 | -1.139 | -0.868 | Decrease | -8 |
| orf3d | F51R | -0.686 | -1.125423 | -1.52 | 0.45 | Decrease | -9 |
| orf3d | L30R | -0.444 | -1.123876 | -0.079 | 0.42 | Decrease | -6 |
| orf3d | G32E | -0.209 | -1.12248 | -0.657 | -0.635 | Increase | -8 |
| orf3d | H19K | -0.543 | -1.119103 | -0.576 | 0.669 | Decrease | -9 |
| orf3d | Q22W | -0.833 | -1.10686 | -0.975 | -0.105 | Decrease | -7 |
| orf3d | H19P | -0.482 | -1.106182 | -0.86 | 0.97 | Increase | -10 |
| orf3d | C44R | -0.769 | -1.104249 | -1.34 | -0.048 | Decrease | -12 |
| orf3d | M1N | -0.913 | -1.098997 | -0.813 | 0.385 | Decrease | -7 |
| orf3d | V43R | -1.452 | -1.098769 | -1.52 | -0.236 | Decrease | -7 |
| orf3d | N18R | -0.376 | -1.088168 | -0.61 | 0.057 | Decrease | -6 |
| orf3d | F51K | -0.618 | -1.072533 | -1.242 | 0.045 | Decrease | -9 |
| orf3d | S34F | -0.168 | -1.060799 | -0.213 | -0.773 | Increase | -6 |
| orf3d | H19D | -0.359 | -1.042116 | -0.769 | -0.132 | Decrease | -9 |
| orf3d | S46I | -0.006 | -1.039833 | -0.333 | -0.195 | Decrease | -6 |
| orf3d | L30K | -0.222 | -1.039502 | 0.251 | 0.053 | Decrease | -6 |
| orf3d | L30W | -0.212 | -1.036663 | 0.807 | -0.555 | Decrease | -6 |
| orf3d | F51N | -0.681 | -1.03494 | -1.659 | 0.11 | Decrease | -9 |
| orf3d | N45L | -0.239 | -1.033058 | -0.184 | 0.088 | Decrease | -9 |
| orf3d | W56R | -0.543 | -1.025585 | -3.068 | -0.148 | Decrease | -14 |
| orf3d | F51D | -0.594 | -1.025115 | -0.688 | 0.666 | Decrease | -9 |
SAR CoV-2 & Human Proteins interaction
To download all protein-protein docking models please see the Help page
| PPI docking | CHARMM_ENERGY | pdb_human | human_genes |
|---|---|---|---|
| HOMA-ORF3d1 | -1030.3 | HOM_A | STOML2 |
| HOMA-ORF3d2 | -1022.8 | HOM_A | STOML2 |
| HOMA-ORF3d3 | -936 | HOM_A | STOML2 |
| HOMA-ORF3d4 | -992.1 | HOM_A | STOML2 |
Protein-Protein Interactions
We have mapped SARS CoV-2 human Protein-Protein Interactions from A SARS-CoV-2 protein interaction map reveals targets for drug repurposing human drug target interacted with SARS CoV-2 are highlighted in black arrow.
