ORF3c
UniProt ITasser SWISS Models alphafold D3Targets-2019-nCoVMay play a role in host modulation.
Models/PDB
No model built for protein with good structural coverage represented in PDB
UniProt Viewer
Predictions of Mutations
| pdb_id | mutations | deepddg | maestro | mCSM_ppi | mCSM_Stability | imutant | provean |
|---|---|---|---|---|---|---|---|
| orf3c | M1E | -0.136 | -1.525027 | 0.12 | 0.324 | Increase | -7 |
| orf3c | M1R | -0.245 | -1.517698 | -0.447 | 0.837 | Decrease | -6 |
| orf3c | M1Q | -0.105 | -1.479911 | -0.274 | 0.326 | Decrease | -5 |
| orf3c | M1K | -0.208 | -1.422302 | -0.255 | 0.396 | Decrease | -6 |
| orf3c | M1D | -0.254 | -1.409692 | 0.106 | 0.367 | Increase | -8 |
| orf3c | L38R | -0.279 | -1.394134 | -0.429 | 0.075 | Decrease | -6 |
| orf3c | L38H | -0.072 | -1.357931 | 0.227 | 0.032 | Decrease | -7 |
| orf3c | H19W | -0.121 | -1.354267 | 0.099 | 0.319 | Increase | -10 |
| orf3c | A37R | -0.039 | -1.351888 | -0.235 | -0.301 | Decrease | -5 |
| orf3c | M1N | -0.187 | -1.342127 | -0.52 | 0.442 | Decrease | -7 |
| orf3c | L38W | -0.046 | -1.283874 | 0.174 | -0.7 | Decrease | -6 |
| orf3c | L33R | -0.669 | -1.261344 | -0.689 | -0.235 | Decrease | -6 |
| orf3c | P18Q | -0.287 | -1.245585 | -0.453 | -0.464 | Decrease | -8 |
| orf3c | A37M | -0.066 | -1.23247 | 0.612 | -0.731 | Decrease | -5 |
| orf3c | Y16Q | -0.228 | -1.225672 | -1.741 | -0.326 | Decrease | -8 |
| orf3c | L38Y | -0.67 | -1.222728 | 0.033 | -0.466 | Decrease | -5 |
| orf3c | L38M | -0.275 | -1.22177 | 0.218 | -0.621 | Decrease | -2 |
| orf3c | Y16R | -0.108 | -1.210706 | -1.733 | 0.087 | Decrease | -9 |
| orf3c | A37K | 0.032 | -1.180073 | 0.039 | -0.762 | Decrease | -5 |
| orf3c | A28M | 0.125 | -1.162103 | -1.2 | 0.297 | Increase | -5 |
| orf3c | Y16E | -0.064 | -1.154569 | -1.502 | 0.334 | Decrease | -9 |
| orf3c | L26Q | -0.293 | -1.146453 | -0.327 | -0.492 | Decrease | -6 |
| orf3c | A37P | 0.175 | -1.141448 | -0.17 | -0.419 | Increase | -5 |
| orf3c | L38Q | -0.326 | -1.140498 | -0.227 | -0.452 | Decrease | -6 |
| orf3c | M1S | -0.336 | -1.125361 | -0.466 | 0.021 | Decrease | -6 |
| orf3c | A37T | -0.271 | -1.124635 | -0.009 | -0.727 | Decrease | -4 |
| orf3c | H30W | -0.065 | -1.118242 | -0.761 | 0.78 | Increase | -10 |
| orf3c | A37N | -0.033 | -1.112891 | -0.064 | -0.496 | Decrease | -6 |
| orf3c | A37F | 0.04 | -1.102673 | 0.502 | -0.963 | Increase | -6 |
| orf3c | P18R | -0.219 | -1.097279 | -0.224 | 0.072 | Decrease | -9 |
| orf3c | A37Q | -0.04 | -1.085021 | 0.163 | -0.744 | Decrease | -5 |
| orf3c | L21Q | -0.104 | -1.081903 | 0.434 | -0.027 | Decrease | -6 |
| orf3c | H30Q | -0.183 | -1.043877 | -0.652 | -1.129 | Increase | -8 |
| orf3c | H30R | -0.162 | -1.040189 | -1.585 | -0.885 | Increase | -8 |
| orf3c | H19R | -0.027 | -1.037945 | -1.336 | -0.498 | Increase | -8 |
| orf3c | P18K | -0.109 | -1.035236 | -0.264 | -0.413 | Decrease | -8 |
| orf3c | L21E | -0.071 | -1.034673 | 0.786 | 0.01 | Decrease | -7 |
| orf3c | A37L | 0.035 | -1.026765 | -0.121 | -0.49 | Decrease | -5 |
| orf3c | A37H | -0.027 | -1.026715 | 0.556 | -0.295 | Decrease | -6 |
| orf3c | Y16K | 0.04 | -1.021957 | -1.501 | -0.19 | Decrease | -9 |
| orf3c | P39N | -0.203 | -1.02088 | -0.107 | -0.263 | Decrease | -9 |
| orf3c | P39K | -0.113 | -1.017553 | 0.087 | -0.449 | Decrease | -8 |
| orf3c | L38E | -0.532 | -1.011602 | 0.125 | -0.467 | Decrease | -7 |
| orf3c | S22E | -0.21 | -1.00647 | -0.35 | 0.214 | Increase | -4 |
| orf3c | H30L | 0.119 | -1.001041 | -1.217 | -0.19 | Increase | -11 |
| orf3c | S22Q | -0.454 | -0.991687 | -0.379 | -0.375 | Increase | -4 |
| orf3c | L38K | 0.047 | -0.986381 | -0.294 | -0.403 | Decrease | -6 |
| orf3c | Y14R | -0.143 | -0.975346 | -1.816 | -0.215 | Decrease | -9 |
| orf3c | R15K | -0.221 | -0.965912 | -0.082 | -0.185 | Decrease | -3 |
| orf3c | P39Q | -0.179 | -0.965792 | 0.137 | -0.448 | Decrease | -8 |
Protein-Protein Interactions
We have mapped SARS CoV-2 human Protein-Protein Interactions from A SARS-CoV-2 protein interaction map reveals targets for drug repurposing human drug target interacted with SARS CoV-2 are highlighted in black arrow.
