ORF3b
UniProt ITasser SWISS Models alphafold D3Targets-2019-nCoVMay play a role in interferon antiviral system evasion. SARS-CoV-2 ORF3b is homologous to SARS-CoV ORF3b, although the proposed protein is much shorter due to the presence of premature stop codons. Elicits strong specific antibody response.
Models/PDB
No model built for protein with good structural coverage represented in PDB
UniProt Viewer
Predictions of Mutations
| pdb_id | mutations | deepddg | maestro | mCSM_ppi | mCSM_Stability | imutant | provean |
|---|---|---|---|---|---|---|---|
| orf3b | G9Q | 0.416 | -1.589684 | -1.804 | -0.628 | Decrease | -8 |
| orf3b | T20R | -0.191 | -1.49607 | -0.52 | -0.075 | Decrease | -6 |
| orf3b | F6E | -0.007 | -1.488943 | -0.999 | 0.756 | Decrease | -9 |
| orf3b | M1N | -0.178 | -1.405557 | -0.464 | 0.41 | Decrease | -7 |
| orf3b | M1E | -0.144 | -1.395846 | 0.197 | 0.08 | Decrease | -7 |
| orf3b | Y18Q | -0.219 | -1.370572 | -1.491 | -0.407 | Decrease | -8 |
| orf3b | Y18R | -0.217 | -1.365159 | -1.738 | 0.019 | Decrease | -9 |
| orf3b | V22Q | -0.241 | -1.33537 | 0.197 | -0.568 | Decrease | -6 |
| orf3b | M1D | -0.174 | -1.317474 | 0.166 | 0.144 | Decrease | -8 |
| orf3b | M1Q | -0.096 | -1.314775 | -0.198 | 0.261 | Decrease | -5 |
| orf3b | V13W | -0.126 | -1.30671 | -0.834 | -0.959 | Decrease | -7 |
| orf3b | M1S | -0.285 | -1.30423 | -0.489 | 0.071 | Decrease | -6 |
| orf3b | F6R | -0.243 | -1.293418 | -1.751 | 0.247 | Decrease | -9 |
| orf3b | M1P | -0.333 | -1.282886 | -0.63 | -0.18 | Decrease | -7 |
| orf3b | V22R | -0.23 | -1.279542 | -0.138 | -0.03 | Decrease | -7 |
| orf3b | T15Q | -0.535 | -1.274866 | -0.445 | -0.426 | Decrease | -6 |
| orf3b | M2R | -0.136 | -1.266473 | -0.728 | 0.754 | Decrease | -6 |
| orf3b | F7E | -0.327 | -1.259664 | -1.107 | 0.769 | Decrease | -9 |
| orf3b | M1R | -0.162 | -1.259277 | -0.585 | 0.585 | Decrease | -6 |
| orf3b | V17Q | -0.431 | -1.249107 | -0.745 | -0.529 | Decrease | -6 |
| orf3b | M2Q | -0.107 | -1.235236 | -0.583 | 0.398 | Decrease | -5 |
| orf3b | G9K | 0.394 | -1.234878 | -2.258 | -0.775 | Decrease | -8 |
| orf3b | V17R | -0.542 | -1.230217 | -1.528 | -0.149 | Decrease | -7 |
| orf3b | V22M | -0.161 | -1.227867 | 0.32 | -0.615 | Decrease | -3 |
| orf3b | I10R | -0.564 | -1.215743 | -0.822 | -0.263 | Decrease | -7 |
| orf3b | Y18E | -0.276 | -1.206183 | -1.121 | 0.932 | Increase | -9 |
| orf3b | T4F | 0.081 | -1.196165 | -0.376 | -0.988 | Decrease | -7 |
| orf3b | F6K | -0.193 | -1.193625 | -1.478 | -0.149 | Decrease | -9 |
| orf3b | I12Q | -0.544 | -1.192751 | -0.839 | -0.521 | Decrease | -7 |
| orf3b | F6Q | -0.083 | -1.188369 | -1.674 | -0.183 | Decrease | -9 |
| orf3b | V22K | -0.149 | -1.182431 | 0.164 | -0.491 | Decrease | -6 |
| orf3b | T15L | 0.204 | -1.173624 | -0.051 | -0.1 | Decrease | -6 |
| orf3b | I10Q | -0.448 | -1.171609 | -0.385 | -0.68 | Decrease | -7 |
| orf3b | I16R | -0.909 | -1.170859 | -1.129 | -0.122 | Decrease | -7 |
| orf3b | G9E | 0.566 | -1.166372 | -1.703 | -0.292 | Increase | -8 |
| orf3b | V17E | -0.56 | -1.162371 | -0.748 | -0.15 | Decrease | -6 |
| orf3b | T14R | -0.499 | -1.154173 | -0.74 | -0.382 | Decrease | -6 |
| orf3b | G9R | 0.192 | -1.15172 | -2.403 | -0.658 | Decrease | -8 |
| orf3b | T4M | -0.075 | -1.138262 | 0.23 | -0.37 | Decrease | -6 |
| orf3b | T20K | -0.075 | -1.134864 | -0.47 | -0.243 | Decrease | -6 |
| orf3b | T15R | -0.635 | -1.132113 | -0.889 | -0.321 | Decrease | -6 |
| orf3b | V13Q | -0.357 | -1.124937 | -1.09 | -0.67 | Decrease | -6 |
| orf3b | M2W | -0.007 | -1.123419 | -0.457 | -0.287 | Decrease | -6 |
| orf3b | V22E | -0.329 | -1.120882 | 0.635 | -0.311 | Decrease | -6 |
| orf3b | T15K | -0.391 | -1.116378 | -0.619 | -0.313 | Decrease | -6 |
| orf3b | T14Q | -0.37 | -1.104944 | -0.233 | -0.502 | Decrease | -6 |
| orf3b | F7Q | -0.346 | -1.09621 | -1.637 | -0.352 | Decrease | -9 |
| orf3b | I12R | -0.639 | -1.09441 | -1.332 | -0.039 | Decrease | -7 |
| orf3b | M1K | -0.156 | -1.092173 | -0.272 | 0.229 | Decrease | -6 |
| orf3b | T4H | -0.091 | -1.092166 | 0.311 | -0.787 | Decrease | -7 |
SAR CoV-2 & Human Proteins interaction
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| PPI docking | CHARMM_ENERGY | pdb_human | human_genes |
|---|---|---|---|
| 1zoqA-ORF3b1 | -950.3 | 1zoq_A | IRF3 |
| 1zoqA-ORF3b2 | -847 | 1zoq_A | IRF3 |
| 1zoqA-ORF3b3 | -878.2 | 1zoq_A | IRF3 |
| 1zoqA-ORF3b4 | -872.7 | 1zoq_A | IRF3 |
Protein-Protein Interactions
We have mapped SARS CoV-2 human Protein-Protein Interactions from A SARS-CoV-2 protein interaction map reveals targets for drug repurposing human drug target interacted with SARS CoV-2 are highlighted in black arrow.
