ORF3a
UniProt ITasser SWISS Models alphafold D3Targets-2019-nCoVForms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release. Up-regulates expression of fibrinogen subunits FGA, FGB and FGG in host lung epithelial cells. Induces apoptosis in cell culture. Downregulates the type 1 interferon receptor by inducing serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and increasing IFNAR1 ubiquitination
Models/PDB
No model built for protein with good structural coverage represented in PDB
Binding Site Predictions
The fpocket calculation in this table only for structure present in the Model/PDB table above.
| fpocket | pocket score | drug score | hydrophobicity score | polarity score |
|---|---|---|---|---|
| pocket0_ORF3a | 23.5 | 0.06 | 19.72 | 13 |
| pocket1_ORF3a | 20.63 | 0.37 | 19.65 | 7 |
| pocket2_ORF3a | 12.28 | 0.78 | 49.22 | 5 |
| pocket3_ORF3a | 9.58 | 0.03 | 12.8 | 11 |
| pocket4_ORF3a | 9.35 | 0.03 | 12.8 | 11 |
| pocket5_ORF3a | 7.41 | 0.01 | 0 | 8 |
| pocket6_ORF3a | 7.31 | 0.01 | 8 | 8 |
| pocket7_ORF3a | 7.1 | 0.01 | 8 | 8 |
| pocket8_ORF3a | 6.32 | 0.02 | 6.45 | 10 |
| pocket9_ORF3a | 5.9 | 0.01 | 22.43 | 5 |
| pocket10_ORF3a | 5.24 | 0.05 | 35.75 | 8 |
| pocket11_ORF3a | 4.37 | 0.01 | -9.6 | 7 |
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Protein-Protein Interactions
We have mapped SARS CoV-2 human Protein-Protein Interactions from A SARS-CoV-2 protein interaction map reveals targets for drug repurposing human drug target interacted with SARS CoV-2 are highlighted in black arrow.
