SARS-CoV-2 3D

Nucleoprotein

UniProt ITasser SWISS Models alphafold D3Targets-2019-nCoV

Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.

Models/PDB

No model built for protein with good structural coverage represented in PDB

Models/PDB	Model Chains_ID	Selected Templates	Model-Quality (MolProbity)	PDB Coverage	Model Coverage	Sequence Length	Oligomer States	Oligomer Interfaces	Model information
N Download Pdb file	A,B	6M3M_A; 2CJR_A; 6K12_A; 1F15_A; 5NP3_A;	3.17	71.12%	87.00%	419	Homo 2-mer	N Download interfaces pdf	N Download model information txt

Models/PDB

Model Chains_ID

Selected Templates

Model-Quality (MolProbity)

PDB Coverage

Model Coverage

Sequence Length

Oligomer States

Oligomer Interfaces

Model information

Download Pdb file

A,B

6M3M_A; 2CJR_A; 6K12_A; 1F15_A; 5NP3_A;

3.17

71.12%

87.00%

419

Homo 2-mer

Download interfaces pdf

Download model information txt

Binding Site Predictions

The fpocket calculation in this table only for structure present in the Model/PDB table above.

fpocket	pocket score	drug score	hydrophobicity score	polarity score
pocket0_N	36.66	0.06	14.7	18
pocket1_N	34.86	0.11	20	17
pocket2_N	32.61	0.12	25.69	18
pocket3_N	30.17	0.13	6.43	16
pocket4_N	28.91	0.39	28.85	10
pocket5_N	20.4	0.02	-1.06	14
pocket6_N	15.64	0.02	24	10
pocket7_N	14.66	0.04	30.1	7
pocket8_N	12.91	0.03	30.62	6
pocket9_N	11.89	0.01	2.46	7
pocket10_N	11.48	0.64	46	1

UniProt Viewer

Other PDB Hits

ID	Method	Resolution Å	Chains	Links
7ce0	X-RAY	1.5	A, B, C, D;	PDBe RCSB PDB
7cdz	X-RAY	1.8	A, B, C, D;	PDBe RCSB PDB
6vyo	X-RAY	1.7	A,B,C,D	PDBe RCSB PDB
6m3m	X-RAY	2.7	A	PDBe RCSB PDB
6yi3	NMR		A	PDBe RCSB PDB
6wji	X-RAY	2.05	A,B	PDBe RCSB PDB
6wkp	X-RAY	2.67	A,B,C,D	PDBe RCSB PDB
6yun	X-RAY	1.44	A,B	PDBe RCSB PDB
7c22	X-RAY	2	A,B	PDBe RCSB PDB
6wzo	X-RAY	1.42	A,B	PDBe RCSB PDB
6wzq	X-RAY	1.45	A,B	PDBe RCSB PDB
6zco	X-RAY	1.36	A,B	PDBe RCSB PDB
7act	NMR		A;	PDBe RCSB PDB
7acs	NMR		A	PDBe RCSB PDB

SAR CoV-2 & Human Proteins interaction

To download all protein-protein docking models please see the Help page

PPI docking	CHARMM_ENERGY	pdb_human	human_genes
6tguA-N.000.27.min Download Pdb file	-21725.71	6tgu_A	CSNK2A2
6tguA-N.003.13.min Download Pdb file	-21618.38	6tgu_A	CSNK2A2
6tguA-N.001.29.min Download Pdb file	-21614.77	6tgu_A	CSNK2A2
6tguA-N.000.07.min Download Pdb file	-21593.7	6tgu_A	CSNK2A2
4dglA-N.000.26.min Download Pdb file	-15741.56	4dgl_A	CSNK2B
4dglA-N.001.17.min Download Pdb file	-15741.56	4dgl_A	CSNK2B
4dglA-N.000.18.min Download Pdb file	-15604.57	4dgl_A	CSNK2B
4dglA-N.001.14.min Download Pdb file	-15595.23	4dgl_A	CSNK2B

Protein-Protein Interactions

We have mapped SARS CoV-2 human Protein-Protein Interactions from A SARS-CoV-2 protein interaction map reveals targets for drug repurposing human drug target interacted with SARS CoV-2 are highlighted in black arrow.