Envelope protein

UniProt ITasser SWISS Models alphafold D3Targets-2019-nCoV

Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis. Activates the host NLRP3 inflammasome, leading to IL-1beta overproduction.

Models/PDB

No model built for protein with good structural coverage represented in PDB

Models/PDB Model Chains_ID Selected Templates Model-Quality (MolProbity) PDB Coverage Model Coverage Sequence Length Oligomer States Oligomer Interfaces Model information
E

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A,B,C,D,E 5X29_A;  3.13 0.00% 76.00% 75 Homo 5-mer

E_ProtCHOIR

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E

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Binding Site Predictions

The fpocket calculation in this table only for structure present in the Model/PDB table above.

fpocket pocket score drug score hydrophobicity score polarity score
pocket0_E 30.18 0.92 45.12 13
pocket1_E 25.85 0.82 50.33 11
pocket2_E 17.6 0.63 47.4 10

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Other PDB Hits

ID Method Resolution Å Chains Links
7k3g NMR A, B, C, D, E; PDBe
RCSB PDB

Protein-Protein Interactions

We have mapped SARS CoV-2 human Protein-Protein Interactions from A SARS-CoV-2 protein interaction map reveals targets for drug repurposing human drug target interacted with SARS CoV-2 are highlighted in black arrow.





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